Drug-Induced Liver Disease 3rd ed.

Drug-Induced Liver Disease 3rd ed.


著者名:Edited by Neil Kaplowitz and Laurie D. DeLeve

出版社:Academic Press






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目次情報 内容紹介 推薦人

Table of Contents
Part I. Mechanisms of Liver Injury
Chapter 1: Drug-Induced Liver Injury: Introduction and Overview
Chapter 2: Cytochrome P450 Activation of Toxins and Hepatotoxicity
Chapter 3: Mechanistic Role of Acyl Glucuronides
Chapter 4: Oxidative Stress, Antioxidant Defense and Liver Injury
Chapter 5: Hepatotoxicity due to Mitochondrial Injury
Chapter 6: Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity
Chapter 7: Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Choles-tasis
Chapter 8: Liver Sinusoidal Endothelial Cell and Liver Injury
Chapter 9: Macrophages and Kupffer Cells in Hepatotoxicity
Chapter 10: Role of Inflammation in Drug-Induced Liver Disease
Chapter 11: Role of Adaptive Immune System
Chapter 12: Role of Tissue Repair in Liver Injury
Chapter 13: Genetic Factors in Pathogenesis
Part II. Diagnosis and Management
Chapter 14: Clinical Manifestations and Management of Drug-Induced Liver Diseases
Chapter 15: Histopathology of Drug-Induced Liver Disease
Chapter 16: Risk Factors for Drug-Induced Liver Disease
Chapter 17: The Promise of Genomics, Proteomics and Metabolomics of Blood and Liver in the Diagnosis of Drug-Induced Liver Disease
Chapter 18: Causality Assessment
Part III. Hepatotoxicity of Specific Drugs
Chapter 19: Mechanisms of Acetaminophen-Induced Liver Disease
Chapter 20: Acetaminophen - Pathology and Clinical Presentation of Hepatotoxicity
Chapter 21: Mechanisms Underlying the Hepatotoxicity of Non-Steroidal Anti-Inflammatory Drugs
Chapter 22: Non-Steroidal Anti-Inflammatory Drugs - Pathology and Clinical Presentation of Hepatotoxicity
Chapter 23: Mechanisms, Pathology and Clinical Presentation of Hepatotoxicity of Anesthetic Agents
Chapter 24: Anticonvulsant AgentsChapter 25: Psychotropic Drugs and Drugs of Abuse
Chapter 26: Hepatotoxicity of Antimicrobials and Antifungal Agents
Chapter 27: Antituberculosis Agents
Chapter 28: Hepatotoxicity in Antiviral Agents
Chapter 29: Hepatotoxicity of Cardiovascular and Antidiabetic Drugs
Chapter 30: Cancer Chemotherapy
Chapter 31: Hepatotoxicity of Immunomodulating Agents and the Transplant Situation
Chapter 32: Methotrexate
Chapter 33: Hormones and Hormone Antagonists
Chapter 34: Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis
Chapter 35: Hepatotoxicity and Herbal Medicines, Vitamins and Natural Hepatoxins
Chapter 36: Occupational and Environmental Hepatotoxicity
Chapter 37: Chronic Liver Disease from Drugs
Part IV. Future Directions
Chapter 38: Regulatory Perspectives
Chapter 39: Drug-Induced Liver Injury Networks
Chapter 40: Liver Tox: The Future